Pulmonary arterial hypertension, a issue in which you have higher blood pressure while in the blood vessels that have blood from your heart to your lungsi.d.) resulted in a 63% lessen of sildenafil AUC plus a 55% lower in sildenafil Cmax . Concomitant administration of robust CYP3A4 inducers, such as rifampin, is expected to cause larger decreases